Polygenic scores stratify neurodevelopmental copy number variant carrier cognitive outcomes in the UK Biobank

Polygenic scores stratify neurodevelopmental copy number variant carrier cognitive outcomes in the UK Biobank

Abstract Rare copy-number variants associated with neurodevelopmental conditions (ND-CNVs) exhibit variable expressivity of clinical, physical, behavioural outcomes. Findings from clinically ascertained cohorts suggest this variability may be partly due to additional genetic variation. Here, we asse...

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Bibliographic Details
Main Authors: Thomas J. Dinneen, Fiana Ní Ghrálaigh, Cathal Ormond, Elizabeth A. Heron, George Kirov, Lorna M. Lopez, Louise Gallagher
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-024-00426-8

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https://doi.org/10.1038/s41525-024-00426-8

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