Defective cholesterol metabolism in amyotrophic lateral sclerosis

Defective cholesterol metabolism in amyotrophic lateral sclerosis

As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels have been linked to prognosis. More than 40 differ...

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Bibliographic Details
Main Authors: Jonas Abdel-Khalik, Eylan Yutuc, Peter J. Crick, Jan-Åke Gustafsson, Margaret Warner, Gustavo Roman, Kevin Talbot, Elizabeth Gray, William J. Griffiths, Martin R. Turner, Yuqin Wang
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Lipid Research
Subjects:
oxysterols
mass spectrometry
cytochrome P450
nuclear receptors/LXR
brain lipids
bile acids and salts/biosynthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520314541

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http://www.sciencedirect.com/science/article/pii/S0022227520314541

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