G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival.

G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival.

Cholesterol derived from the host milieu forms a critical factor for mycobacterial pathogenesis. However, the molecular circuitry co-opted by Mycobacterium tuberculosis (Mtb) to accumulate cholesterol in host cells remains obscure. Here, we report that the coordinated action of WNT-responsive histon...

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Bibliographic Details
Main Authors: Praveen Prakhar, Bharat Bhatt, Gaurav Kumar Lohia, Awantika Shah, Tanushree Mukherjee, Ullas Kolthur-Seetharam, Nagalingam R Sundaresan, Raju S Rajmani, Kithiganahalli Narayanaswamy Balaji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-10-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011731&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011731&type=printable

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