The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

The CD33 short isoform is a gain-of-function variant that enhances Aβ1–42 phagocytosis in microglia

Abstract Background CD33 is genetically linked to Alzheimer’s disease (AD) susceptibility through differential expression of isoforms in microglia. The role of the human CD33 short isoform (hCD33m), preferentially encoded by an AD-protective CD33 allele (rs12459419T), is unknown. Here, we test wheth...

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Bibliographic Details
Main Authors: Abhishek Bhattacherjee, Jaesoo Jung, Sameera Zia, Madelene Ho, Ghazaleh Eskandari-Sedighi, Chris D. St. Laurent, Kelli A. McCord, Arjun Bains, Gaurav Sidhu, Susmita Sarkar, Jason R. Plemel, Matthew S. Macauley
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
CD33
Immunomodulatory
Isoform
Microglia
Phagocytosis
Online Access:https://doi.org/10.1186/s13024-021-00443-6

Internet

https://doi.org/10.1186/s13024-021-00443-6

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