Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

Novel transketolase inhibitor oroxylin A suppresses the non‐oxidative pentose phosphate pathway and hepatocellular carcinoma tumour growth in mice and patient‐derived organoids

Abstract Background Transketolase (TKT), a key rate‐limiting enzyme in the non‐oxidative branch of the pentose phosphate pathway (PPP), provides more than 85% of the ribose required for de novo nucleotide biosynthesis and promotes the development of hepatocellular carcinoma (HCC). Pharmacologic inhi...

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Bibliographic Details
Main Authors: Dan Jia, Chunliang Liu, Zhenyu Zhu, Yan Cao, Wen Wen, Zhanying Hong, Yue Liu, Erdong Liu, Long Chen, Chun Chen, Yanqiu Gu, Binghua Jiao, Yifeng Chai, Hong‐yang Wang, Jing Fu, Xiaofei Chen
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Clinical and Translational Medicine
Subjects:
metabolic reprogramming
non‐oxidative pentose phosphate pathway
oroxylin A
patient‐derived organoids
transketolase
Online Access:https://doi.org/10.1002/ctm2.1095

Internet

https://doi.org/10.1002/ctm2.1095

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