PDX models of human lung squamous cell carcinoma: consideration of factors in preclinical and co-clinical applications

PDX models of human lung squamous cell carcinoma: consideration of factors in preclinical and co-clinical applications

Abstract Background Treatment of human lung squamous cell carcinoma (LUSC) using current targeted therapies is limited because of their diverse somatic mutations without any specific dominant driver mutations. These mutational diversities preventing the use of common targeted therapies or the combin...

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Main Authors: Hae-Yun Jung, Tae Ho Kim, Jong-Eun Lee, Hong Kwan Kim, Jong Ho Cho, Yong Soo Choi, Sumin Shin, Se-Hoon Lee, Hwanseok Rhee, Hee Kyung Lee, Hyun Jung Choi, Hye Yoon Jang, Seungjae Lee, Jung Hee Kang, Young Ae Choi, Sanghyuk Lee, Jinseon Lee, Yoon La Choi, Jhingook Kim
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Translational Medicine
Subjects:
Lung squamous cell carcinoma
Patient-derived xenograft
Engraftment
Preclinical model
Xenograft-associated lymphoproliferative disease
Online Access:http://link.springer.com/article/10.1186/s12967-020-02473-y

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http://link.springer.com/article/10.1186/s12967-020-02473-y

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