Administration of RANKL boosts thymic regeneration upon bone marrow transplantation

Administration of RANKL boosts thymic regeneration upon bone marrow transplantation

Abstract Cytoablative treatments lead to severe damages on thymic epithelial cells (TECs), which result in delayed de novo thymopoiesis and a prolonged period of T‐cell immunodeficiency. Understanding the mechanisms that govern thymic regeneration is of paramount interest for the recovery of a funct...

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Bibliographic Details
Main Authors: Noella Lopes, Hortense Vachon, Julien Marie, Magali Irla
Format: Article
Language:English
Published: Springer Nature 2017-06-01
Series:EMBO Molecular Medicine
Subjects:
bone marrow transplantation
lymphotoxin α
receptor activator of nuclear factor kappa B ligand
T‐cell reconstitution
thymic regeneration
Online Access:https://doi.org/10.15252/emmm.201607176

Internet

https://doi.org/10.15252/emmm.201607176

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