The Antimicrobial Peptide lin-SB056-1 and Its Dendrimeric Derivative Prevent Pseudomonas aeruginosa Biofilm Formation in Physiologically Relevant Models of Chronic Infections

The Antimicrobial Peptide lin-SB056-1 and Its Dendrimeric Derivative Prevent Pseudomonas aeruginosa Biofilm Formation in Physiologically Relevant Models of Chronic Infections

Antimicrobial peptides (AMPs) are promising templates for the development of novel antibiofilm drugs. Despite the large number of studies on screening and optimization of AMPs, only a few of these evaluated the antibiofilm activity in physiologically relevant model systems. Potent in vitro activity...

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Bibliographic Details
Main Authors: Lucia Grassi, Giovanna Batoni, Lisa Ostyn, Petra Rigole, Sara Van den Bossche, Andrea C. Rinaldi, Giuseppantonio Maisetta, Semih Esin, Tom Coenye, Aurélie Crabbé
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial peptides
dendrimeric peptide
combination treatment
biofilm
Pseudomonas aeruginosa
3-D lung epithelial cell model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00198/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00198/full

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