Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Association of lithocholic acid with skeletal muscle hypertrophy through TGR5-IGF-1 and skeletal muscle mass in cultured mouse myotubes, chronic liver disease rats and humans

Background: Hepatic sarcopenia is one of many complications associated with chronic liver disease (CLD) and has a high mortality rate; however, the liver-muscle axis is not fully understood. Therefore, few effective treatments exist for hepatic sarcopenia, the best of which being branched-chain amin...

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Bibliographic Details
Main Authors: Yasuyuki Tamai, Akiko Eguchi, Ryuta Shigefuku, Hiroshi Kitamura, Mina Tempaku, Ryosuke Sugimoto, Yoshinao Kobayashi, Motoh Iwasa, Yoshiyuki Takei, Hayato Nakagawa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
chronic liver diseases
low muscle mass
skeletal muscle
bile acids
lithocholic acid
liver-muscle axis
Online Access:https://elifesciences.org/articles/80638

Internet

https://elifesciences.org/articles/80638

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