Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are Resistant to Endocrine Therapy and CDK4/6 Inhibitors

Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are Resistant to Endocrine Therapy and CDK4/6 Inhibitors

Despite the success of antiestrogens in extending overall survival of patients with estrogen receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ER+ tumors that progress on antiestrogens are treated with antiestrogens and CDK4/6 inhibitors. However, 20% of these tumors...

Full description

Bibliographic Details
Main Authors: Yassi Fallah, Diane M. Demas, Lu Jin, Wei He, Ayesha N. Shajahan-Haq
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
estrogen receptor positive breast cancer
endocrine therapy
drug resistance
CDK4/6 inhibitors
ribociclib
WEE1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.681530/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.681530/full

Similar Items