Phosphate Precipitates and Water-Soluble Aggregates in Re-analyzed Solubility-pH Data of Twenty-five Basic Drugs

The purpose of the study was to assess the stoichiometries of phosphate precipitates and determine the intrinsic solubilities, S0, of 25 basic drugs from their published solubility-pH profiles in the landmark study of Bergström et al. (2004), where 0.15 M phosphate buffer media had been used. A sec...

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Bibliographic Details
Main Author: Alex Avdeef
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2014-04-01
Series:ADMET and DMPK
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/31