The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules

The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules

Chronic hepatitis B virus (HBV), a potentially life-threatening liver disease, makes people vulnerable to serious diseases such as cancer. T lymphocytes play a crucial role in clearing HBV virus, while the pathway depends on the strong binding of T cell epitope peptide and HLA. However, the experime...

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Bibliographic Details
Main Authors: Xueyin Mei, Xingyu Li, Chen Zhao, Anna Liu, Yan Ding, Chuanlai Shen, Jian Li
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis B virus
affinity
MM-GBSA
residue scanning
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/9/4629

Internet

https://www.mdpi.com/1422-0067/23/9/4629

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