Correcting modification-mediated errors in nanopore sequencing by nucleotide demodification and reference-based correction
Abstract The accuracy of Oxford Nanopore Technology (ONT) sequencing has significantly improved thanks to new flowcells, sequencing kits, and basecalling algorithms. However, novel modification types untrained in the basecalling models can seriously reduce the quality. Here we reports a set of ONT-s...
| Autors principals: | , , , , , |
|---|---|
| Format: | Article |
| Idioma: | English |
| Publicat: |
Nature Portfolio
2023-11-01
|
| Col·lecció: | Communications Biology |
| Accés en línia: | https://doi.org/10.1038/s42003-023-05605-4 |