Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal development, survival and death. Numerous data suggest that nicotinamide may offer therapeutic benefits in neurodegenerative disorders, includ...

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Bibliographic Details
Main Authors: Felipe Salech, Daniela P. Ponce, Andrea C. Paula-Lima, Carol D. SanMartin, María I. Behrens
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
nicotinamide
PARP-1 inhibitors
Alzheimer’s disease therapy
oxidative death
lymphocytes
parthanatos
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00255/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00255/full

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