Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment

Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment

Abstract Accumulating evidence highlights the involvement of astrocytes in Alzheimer’s disease (AD) progression. We have previously demonstrated that human iPSC-derived astrocytes ingest and modify synthetic tau fibrils in a way that enhances their seeding efficiency. However, synthetic tau fibrils...

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Bibliographic Details
Main Authors: Khalid Eltom, Tobias Mothes, Sylwia Libard, Martin Ingelsson, Anna Erlandsson
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Tau
Astrocytes
Brain-derived fibrils
Inflammation
Neurons
Online Access:https://doi.org/10.1186/s40478-024-01745-8

Internet

https://doi.org/10.1186/s40478-024-01745-8

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