NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection

NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection

Lymphatic filariasis and onchocerciasis are major neglected tropical diseases affecting over 90 million people worldwide with painful and profoundly disfiguring pathologies (such as lymphoedema or blindness). Type 2 inflammation is a hallmark of filarial nematode tissue infection and is implicated b...

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Bibliographic Details
Main Authors: Nicolas Pionnier, Julio Furlong-Silva, Stefano A. P. Colombo, Amy E. Marriott, Valerine C. Chunda, Bertrand L. Ndzeshang, Hanna Sjoberg, John Archer, Andrew Steven, Samuel Wanji, Mark J. Taylor, Joseph D. Turner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
natural killer cells (NK cells)
lymphatic filariasis
Brugia malayi
innate lymphoid cells (ILC)
eosinophils
Rag2 knockout (KO) mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.969340/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.969340/full

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