Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents

Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the dur...

Full description

Bibliographic Details
Main Authors: Oakley C. Olson, Hyunjung Kim, Daniela F. Quail, Emily A. Foley, Johanna A. Joyce
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
macrophage
Taxol
antimitotic
mitotic arrest
mitotic slippage
tetraploid
chemotherapy
chemoresistance
microenvironment
breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303844

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717303844

Similar Items