Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance

Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance

Background Despite the remarkable success of immunotherapy in treating melanoma, understanding of the underlying mechanisms of resistance remains limited. Emerging evidence suggests that upregulation of tumor-specific major histocompatibility complex-II (tsMHC-II) serves as a predictive marker for t...

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Bibliographic Details
Main Authors: Violeta Sánchez, Yaomin Xu, Douglas B Johnson, Emily Hodges, Margaret L Axelrod, Justin M Balko, Xiaopeng Sun, Brandie C Taylor, Catherine C Fahey, Jamaal L James, Lindsey N Guerin, Paula I Gonzalez-Ericsson, Melinda E Sanders
Format: Article
Language:English
Published: BMJ Publishing Group 2023-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/11/e007736.full

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https://jitc.bmj.com/content/11/11/e007736.full

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