β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia

BackgroundPerturbed balance between NO and O2•−. (ie, NO/redox imbalance) is central in the pathobiology of diabetes‐induced vascular dysfunction. We examined whether stimulation of β3 adrenergic receptors (β3 ARs), coupled to endothelial nitric oxide synthase (eNOS) activation, would re‐establish N...

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Bibliographic Details
Main Authors: Keyvan Karimi Galougahi, Chia‐Chi Liu, Alvaro Garcia, Carmine Gentile, Natasha A. Fry, Elisha J. Hamilton, Clare L. Hawkins, Gemma A. Figtree
Format: Article
Language:English
Published: Wiley 2016-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
β3 adrenergic receptors
endothelial dysfunction
endothelial nitric oxide synthase
hyperglycemia
oxidative stress
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002824

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.115.002824

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