USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses

USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses

Toll-like receptors (TLRs) are involved in the sensing of pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS), flagellin, unmethylated double-stranded DNA (CpG), single-stranded RNA (ssRNA) and lipoproteins. Myeloid differentiation primary response protein 88 (MyD88) is a...

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Bibliographic Details
Main Authors: Na Zhang, Fei Wang, Gaomeng Zhang, Qi Zhang, Yuhong Liu, Qiao Wang, Mohamed Shafey Elsharkawy, Maiqing Zheng, Jie Wen, Guiping Zhao, Qinghe Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
USP7
MyD88
deubiquitinase
cytokines
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.900243/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.900243/full

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