Minimal Residual Disease Detection at RNA and Leukemic Stem Cell (LSC) Levels: Comparison of RT-qPCR, d-PCR and CD26+ Stem Cell Measurements in Chronic Myeloid Leukemia (CML) Patients in Deep Molecular Response (DMR)

Minimal Residual Disease Detection at RNA and Leukemic Stem Cell (LSC) Levels: Comparison of RT-qPCR, d-PCR and CD26+ Stem Cell Measurements in Chronic Myeloid Leukemia (CML) Patients in Deep Molecular Response (DMR)

A Deep Molecular Response (DMR), defined as a <i>BCR::ABL1</i> transcript at levels ≤ 0.01% by RT-qPCR, is the prerequisite for the successful interruption of treatment among patients with Chronic Myeloid Leukemia (CML). However, approximately 50% of patients in Treatment-Free Remission...

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Bibliographic Details
Main Authors: Elisabetta Abruzzese, Monica Bocchia, Malgorzata Monika Trawinska, Donatella Raspadori, Francesco Bondanini, Anna Sicuranza, Paola Pacelli, Federica Re, Alessia Cavalleri, Mirko Farina, Michele Malagola, Domenico Russo, Paolo De Fabritiis, Simona Bernardi
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
chronic myeloid leukemia
minimal residual disease
<i>BCR::ABL1</i>
RT-qPCR
digital PCR
leukemic stem cells
Online Access:https://www.mdpi.com/2072-6694/15/16/4112

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https://www.mdpi.com/2072-6694/15/16/4112

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