p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer

p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer

Background: Aberrant androgen receptor (AR) signaling is a major driver of castration-resistant prostate cancer (CRPC). Tumor hypoxia increases AR signaling and is associated with treatment resistance in prostate cancer. Heat shock protein 27 (Hsp27) is a molecular chaperone that is activated in res...

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Bibliographic Details
Main Authors: Serina Cheung, Pallavi Jain, Jonathan So, Saeid Shahidi, Stephen Chung, Marianne Koritzinsky
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
castration-resistant prostate cancer
hypoxia
androgen receptor
p38 MAPK
Hsp27
xenograft
Online Access:https://www.mdpi.com/2072-6694/13/4/831

Internet

https://www.mdpi.com/2072-6694/13/4/831

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