Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5

Competitive Binding of Ozanimod and Other Sphingosine 1-Phosphate Receptor Modulators at Receptor Subtypes 1 and 5

Ozanimod, a sphingosine 1-phosphate (S1P) receptor modulator, binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5), and is approved in multiple countries for treating adults with relapsing forms of multiple sclerosis (MS) or moderately to severely active ulcerative col...

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Bibliographic Details
Main Authors: Julie V. Selkirk, Andrea Bortolato, Yingzhuo Grace Yan, Nathan Ching, Richard Hargreaves
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
G protein-coupled receptor
multiple sclerosis
orthosteric binding site
radioligand binding
sphingosine 1-phosphate
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.892097/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.892097/full

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