Multiple-dose up-titration study to evaluate the pharmacokinetics, safety and antitumor activity of apatinib in advanced gastric adenocarcinoma

Multiple-dose up-titration study to evaluate the pharmacokinetics, safety and antitumor activity of apatinib in advanced gastric adenocarcinoma

Background and purposeThe objective of this study was to investigate the pharmacokinetics, safety, and antitumor activity of apatinib, a vascular endothelial growth factor receptor 2 inhibitor, in advanced gastric adenocarcinoma or gastroesophageal junction adenocarcinoma and evaluate the effect of...

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Bibliographic Details
Main Authors: Yonggang Wang, Chang Wang, Yanqiao Zhang, Jiqing Hao, Nong Yang, Jvfeng Wang, Min Peng, Tianshu Liu, Guifang Zhang, Xianbao Zhan, Shan Zeng, Yifan Zhang, Yong Gao, Yang Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
apatinib
angiogenesis
gastric adenocarcinoma
pharmacokinetics
VEGFR
VEGFR-2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.876899/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.876899/full

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