Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis

Intrarenal Arterial Transplantation of Dexmedetomidine Preconditioning Adipose Stem-Cell-Derived Microvesicles Confers Further Therapeutic Potential to Attenuate Renal Ischemia/Reperfusion Injury through miR-122-5p/Erythropoietin/Apoptosis Axis

Intravenous adipose mesenchymal stem cells (ADSCs) attenuate renal ischemia/reperfusion (IR) injury but with major drawbacks, including the lack of a specific homing effect after systemic infusion, cell trapping in the lung, and early cell death in the damaged microenvironment. We examined whether i...

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Bibliographic Details
Main Authors: Yu-Hsuan Cheng, Kuo-Hsin Chen, Yi-Ting Sung, Chih-Ching Yang, Chiang-Ting Chien
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
adipose-derived mesenchymal stem cells
apoptosis
dexmedetomidine preconditioning
erythropoietin
ischemia/reperfusion
microvesicles
Online Access:https://www.mdpi.com/2076-3921/11/9/1702

Internet

https://www.mdpi.com/2076-3921/11/9/1702

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