EZH2–CCF–cGAS Axis Promotes Breast Cancer Metastasis

EZH2–CCF–cGAS Axis Promotes Breast Cancer Metastasis

Cytoplasmic chromatin fragments (CCF) are recognized by the cytoplasmic DNA sensor cyclic GMP-AMP synthase (cGAS), which activates the cGAS–STING (cyclic GMP-AMP synthase-stimulator of interferon genes) pathway and promotes the production of inflammatory factors and breast cancer metastasis. However...

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Bibliographic Details
Main Authors: Dandan Duan, Mengjie Shang, Yanxu Han, Jiayuan Liu, Jiwei Liu, Sun Hyok Kong, Jingyao Hou, Baiqu Huang, Jun Lu, Yu Zhang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer metastasis
cytoplasmic chromatin fragments
EZH2
cGAS
USP7
Online Access:https://www.mdpi.com/1422-0067/23/3/1788

Internet

https://www.mdpi.com/1422-0067/23/3/1788

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