A homeostatic model of IκB metabolism to control constitutive NF‐κB activity

Abstract Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state. The transcription factor NF‐κB is typically described as being hel...

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Bibliographic Details
Main Authors: Ellen L O'Dea, Derren Barken, Raechel Q Peralta, Kim T Tran, Shannon L Werner, Jeffrey D Kearns, Andre Levchenko, Alexander Hoffmann
Format: Article
Language:English
Published: Springer Nature 2007-05-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb4100148