Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains

Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains

The main goal of the study was to characterize the behavioral and metabolomic profiles of repeated administration (for 11 days) of d-amphetamine (AMPH, 3 mg/kg i. p.), indirect agonist of dopamine (DA), in widely used 129S6/SvEvTac (129Sv) and C57BL/6NTac (Bl6) mouse strains. Acute administration of...

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Bibliographic Details
Main Authors: Taavi Vanaveski, Jane Narvik, Jürgen Innos, Mari-Anne Philips, Aigar Ottas, Mario Plaas, Liina Haring, Mihkel Zilmer, Eero Vasar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Neuroscience
Subjects:
amphetamine
repeated administration
locomotor activity
behavioral sensitization
129Sv strain
Bl6 strain
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00399/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00399/full

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