SARS-CoV-2 Spike protein alters microglial purinergic signaling

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of viral brain replication resulting in activation o...

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Bibliographic Details
Main Authors: Vinícius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antônio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Cláudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2 spike protein
COVID-19
ectonucleotidase
P2 receptors
CD39
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158460/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1158460/full

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