Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis

Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis

ABSTRACT Long-term macrolide therapy reduces rates of pulmonary exacerbation in bronchiectasis. However, little is known about the potential for macrolide therapy to alter the composition and function of the oropharyngeal commensal microbiota or to increase the carriage of transmissible antimicrobia...

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Bibliographic Details
Main Authors: Jocelyn M. Choo, Guy C. J. Abell, Rachel Thomson, Lucy Morgan, Grant Waterer, David L. Gordon, Steven L. Taylor, Lex E. X. Leong, Steve L. Wesselingh, Lucy D. Burr, Geraint B. Rogers
Format: Article
Language:English
Published: American Society for Microbiology 2018-04-01
Series:mSphere
Subjects:
antibiotic resistance
bronchiectasis
macrolide therapy
oropharyngeal microbiome
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00103-18

Internet

https://journals.asm.org/doi/10.1128/mSphere.00103-18

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