Emerging SARS-CoV-2 variants expand species tropism to murines

Emerging SARS-CoV-2 variants expand species tropism to murines

Background: Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-CoV-2 variants, including B.1.1.7, B.1.351, P.1, and P.3, contain mutations in spike that has been suggested to associate with an increased recognition of mouse ACE2, raising the postulation that these SARS-CoV-2 va...

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Bibliographic Details
Main Authors: Huiping Shuai, Jasper Fuk-Woo Chan, Terrence Tsz-Tai Yuen, Chaemin Yoon, Jing-Chu Hu, Lei Wen, Bingjie Hu, Dong Yang, Yixin Wang, Yuxin Hou, Xiner Huang, Yue Chai, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Lu Lu, Rui-Qi Zhang, Wan-Mui Chan, Jonathan Daniel Ip, Allen Wing-Ho Chu, Ye-Fan Hu, Jian-Piao Cai, Kwok-Hung Chan, Jie Zhou, Siddharth Sridhar, Bao-Zhong Zhang, Shuofeng Yuan, Anna Jinxia Zhang, Jian-Dong Huang, Kelvin Kai-Wang To, Kwok-Yung Yuen, Hin Chu
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:EBioMedicine
Subjects:
SARS-CoV-2 variants
mouse
rat
murine
susceptibility
N501Y
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421004369

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http://www.sciencedirect.com/science/article/pii/S2352396421004369

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