Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBV

Design and analysis considerations for early phase clinical trials in hepatitis B (HBV) cure research: the ACTG A5394 study in persons with both HIV and HBV

With growing interest and efforts to achieve a hepatitis B (HBV) cure, HBV therapeutics have increasingly entered the clinical testing phase. In designing an early phase clinical trial aimed at HBV cure, the heterogeneity in participants and the choice of a biomarker endpoint that signals a cure req...

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Bibliographic Details
Main Authors: Minhee Kang, Jennifer C. Price, Marion G. Peters, Sharon R. Lewin, Mark Sulkowski
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Virus Eradication
Subjects:
HBV
HIV
Cure
Clinical trial design
Placebo
TLR agonist
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664023000304

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http://www.sciencedirect.com/science/article/pii/S2055664023000304

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