Rules and mechanisms governing G protein coupling selectivity of GPCRs

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13. However, our understanding of the G protein selectivity of GPCRs is incomplete. Here, we quantitatively measure...

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Bibliographic Details
Main Authors: Ikuo Masuho, Ryoji Kise, Pablo Gainza, Ee Von Moo, Xiaona Li, Ryosuke Tany, Hideko Wakasugi-Masuho, Bruno E. Correia, Kirill A. Martemyanov
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723011853

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http://www.sciencedirect.com/science/article/pii/S2211124723011853

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