Discovery of an Experimental Model of Unicuspid Aortic Valve

Discovery of an Experimental Model of Unicuspid Aortic Valve

Background The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss‐of‐function mutation in epithelial growth factor receptor, which are EgfrVel/+ mice, would develop anomalous aorti...

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Bibliographic Details
Main Authors: Robert M. Weiss, Yi Chu, Robert M. Brooks, Donald D. Lund, Justine Cheng, Kathy A. Zimmerman, Melissa K. Kafa, Phanicharan Sistla, Hardik Doshi, Jian Q. Shao, Ramzi N. El Accaoui, Catherine M. Otto, Donald D. Heistad
Format: Article
Language:English
Published: Wiley 2018-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aortic valve
aortic valve regurgitation
aortic valve stenosis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006908

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006908

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