Multispectroscopic and computational insights into amyloid fibril formation of alpha lactalbumin induced by sodium hexametaphosphate

Multispectroscopic and computational insights into amyloid fibril formation of alpha lactalbumin induced by sodium hexametaphosphate

Abstract The impact of sodium hexametaphosphate (SHMP) on the aggregation behavior of α-lactalbumin (α-LA) was studied at pH 7.4 and 2.0. Turbidity measurements showed a concentration-dependent aggregation of α-LA at pH 2.0 in the presence of SHMP, while no aggregation was observed at pH 7.4. Light...

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Bibliographic Details
Main Authors: Nasser Abdulatif Al-Shabib, Javed Masood Khan, Ajamaluddin Malik, Md Tabish Rehman, Abdulaziz Alamri, Vijay Kumar, Per Erik Joakim Saris, Fohad Mabood Husain, Mohamed F AlAjmi
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Amyloid fibril
Protein conformation
Stability
Alpha-lactalbumin
Sodium hexametaphosphate
ThT
Online Access:https://doi.org/10.1038/s41598-024-80897-y

Internet

https://doi.org/10.1038/s41598-024-80897-y

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