Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss

Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss

Background: Mitochondrial dysfunction is considered to contribute to the development of age-related hearing loss (AHL). The regulation of mitochondrial function requires mitochondrial quality control, which includes mitophagy and dynamics. Dynamin-related Protein 1 (DRP-1) is believed to play a cent...

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Bibliographic Details
Main Authors: Hanqing Lin, Hao Xiong, Zhongwu Su, Jiaqi Pang, Lan Lai, Huasong Zhang, Bingquan Jian, Weijian Zhang, Yiqing Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
presbycusis
oxidative stress
DRP-1
mitophagy
cochlea
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00550/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00550/full

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