The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

The rapid activation of pattern recognition receptor (PRR)-mediated type I interferon (IFN) signaling is crucial for the host response to infection. In turn, human cytomegalovirus (HCMV) must evade this potent response to establish life-long infection. Here, we reveal that the HCMV tegument protein...

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Bibliographic Details
Main Authors: Markus Fabits, Vladimir Gonçalves Magalhães, Baca Chan, Virginie Girault, Endrit Elbasani, Elisa Rossetti, Eirikur Saeland, Martin Messerle, Andreas Pichlmair, Vanda Juranić Lisnić, Melanie M. Brinkmann
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Microorganisms
Subjects:
herpesvirus
cytomegalovirus
pattern recognition receptor
cGAS
STING
RIG-I
Online Access:https://www.mdpi.com/2076-2607/8/6/790

Internet

https://www.mdpi.com/2076-2607/8/6/790

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