Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in mice.

Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in mice.

In this study, we tested the hypothesis that rectal immunization with a VCG-based chlamydial vaccine would cross-protect mice against heterologous genital Chlamydia trachomatis infection and Chlamydia-induced upper genital tract pathologies in mice. Female mice were immunized with a C. trachomatis s...

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Bibliographic Details
Main Authors: Roshan Pais, Yusuf Omosun, Qing He, Uriel Blas-Machado, Carolyn Black, Joseph U Igietseme, Kohtaro Fujihashi, Francis O Eko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5453548?pdf=render

Internet

http://europepmc.org/articles/PMC5453548?pdf=render

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