Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells

Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells

Besides being a marker of kidney disease severity, albuminuria exerts a toxic effect on renal proximal tubular epithelial cells (RPTECs). We evaluated whether an unfolded protein response (UPR) or DNA damage response (DDR) is elicited in RPTECs exposed to high albumin concentration. The deleterious...

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Bibliographic Details
Main Authors: Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Christina Poulianiti, Maria Anna Polyzou Konsta, Vassilios Liakopoulos, Ioannis Stefanidis
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
albumin
renal tubular epithelial cells
endoplasmic reticulum stress
DNA damage
apoptosis
senescence
Online Access:https://www.mdpi.com/1422-0067/24/11/9640

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https://www.mdpi.com/1422-0067/24/11/9640

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