The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2

In the fight against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), monoclonal antibodies (mAbs) serve as key strategies for the rapid prevention and treatment of COVID-19. However, analysis to fully characterize functional SARS-CoV-2 mAbs is still needed. In this study, by interrogat...

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Bibliographic Details
Main Authors: Xiaolong Tian, Xiaoyi Zhu, Wenping Song, Zhenlin Yang, Yanling Wu, Tianlei Ying
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
monoclonal antibody
somatic hypermutation
IGHV3-53/3-66
antibody affinity
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2063074

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https://www.tandfonline.com/doi/10.1080/22221751.2022.2063074

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