Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models

Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models

Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects have been reported for different ALOX-isoforms. Human ALOX15B oxygenates arachidonic acid to its 15-hydroperoxy derivative, whereas the corre...

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Bibliographic Details
Main Authors: Marjann Schäfer, Florian Reisch, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kuhn
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
eicosanoids
lipids
metabolism
fatty acids
inflammation
atherosclerosis
Online Access:https://www.mdpi.com/1422-0067/24/13/11034

Internet

https://www.mdpi.com/1422-0067/24/13/11034

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