Identification of a Cancer-Predisposing Germline <i>POT1</i> p.Ile49Metfs*7 Variant by Targeted Sequencing of a Splenic Marginal Zone Lymphoma

Identification of a Cancer-Predisposing Germline <i>POT1</i> p.Ile49Metfs*7 Variant by Targeted Sequencing of a Splenic Marginal Zone Lymphoma

Germline disruptive variants in <i>Protection of Telomeres 1</i> (<i>POT1</i>) predispose to a wide variety of cancers, including melanoma, chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, myeloproliferative neoplasms, and glioma. We report the first case of splenic marg...

Full description

Bibliographic Details
Main Authors: Audrey N. Jajosky, Anna L. Mitchell, Mahmut Akgul, Shashirekha Shetty, Jennifer M. Yoest, Stanton L. Gerson, Navid Sadri, Kwadwo A. Oduro
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Genes
Subjects:
hereditary cancer predisposition
germline <i>POT1</i> alteration
splenic marginal zone lymphoma
cancer genetics
Online Access:https://www.mdpi.com/2073-4425/13/4/591

Internet

https://www.mdpi.com/2073-4425/13/4/591

Similar Items