Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models

Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models

Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the brain parenchymal fraction (BPF) and T2 hyperintense lesion volume (T2LV), and...

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Bibliographic Details
Main Authors: Alicia S. Chua, MS, Svetlana Egorova, MD, PhD, Mark C. Anderson, MS, Mariann Polgar-Turcsanyi, MS, Tanuja Chitnis, MD, Howard L. Weiner, MD, Charles R.G. Guttmann, MD, Rohit Bakshi, MD, Brian C. Healy, PhD
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:NeuroImage: Clinical
Subjects:
Multiple sclerosis
MRI
Brain atrophy
T2 lesion
Mixed-effect models
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158215001151

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http://www.sciencedirect.com/science/article/pii/S2213158215001151

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