Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca<sup>2+</sup> Overload for the Treatment of Neurodegenerative Diseases and Stroke

Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca<sup>2+</sup> Overload for the Treatment of Neurodegenerative Diseases and Stroke

In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca<sup>2+</sup> levels. A dysregulation of the mitochondrial Ca<sup>2+</sup> buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitochond...

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Bibliographic Details
Main Authors: Lucía Viejo, Marcos Rubio-Alarcón, Raquel L. Arribas, Manuel Moreno-Castro, Raquel Pérez-Marín, María Braun-Cornejo, Martín Estrada-Valencia, Cristóbal de los Ríos
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
CGP37157
benzothiazepines
neuroprotection
Ca<sup>2+</sup> overload
oxidative stress
mitochondria
Online Access:https://www.mdpi.com/1420-3049/26/15/4473

Internet

https://www.mdpi.com/1420-3049/26/15/4473

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