Family reunion via error correction: an efficient analysis of duplex sequencing data

Family reunion via error correction: an efficient analysis of duplex sequencing data

Abstract Background Duplex sequencing is the most accurate approach for identification of sequence variants present at very low frequencies. Its power comes from pooling together multiple descendants of both strands of original DNA molecules, which allows distinguishing true nucleotide substitutions...

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Bibliographic Details
Main Authors: Nicholas Stoler, Barbara Arbeithuber, Gundula Povysil, Monika Heinzl, Renato Salazar, Kateryna D Makova, Irene Tiemann-Boege, Anton Nekrutenko
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Bioinformatics
Subjects:
Duplex sequence
Low frequency variants
Barcodes
Error correction
Online Access:http://link.springer.com/article/10.1186/s12859-020-3419-8

Internet

http://link.springer.com/article/10.1186/s12859-020-3419-8

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