AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice

BackgroundVascular endothelial growth factors (VEGFs) are major regulators of intratumoral angiogenesis in ovarian cancer (OVCA). Overexpression of VEGFs is associated with increased tumor growth and metastatic tendency and VEGF-targeting therapies are thus considered as potential treatments for OVC...

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Bibliographic Details
Main Authors: Anni Kujala, Elina Valkonen, Hanna Sallinen, Laura Tuppurainen, Hanne Laakso, Elias Ylä-Herttuala, Timo Liimatainen, Jouni Kujala, Otto Jokelainen, Reijo Sironen, Maarit Anttila, Seppo Ylä-Herttuala
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Medicine
Subjects:
angiogenesis
lymphangiogenesis
antiangiogenic
MRI
xenograft
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1018208/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.1018208/full

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