Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment

Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment

Human health risk assessment is historically built upon animal testing, often following Organisation for Economic Co-operation and Development (OECD) test guidelines and exposure assessments. Using combinations of human relevant in vitro models, chemical analysis and computational (in silico) approa...

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Bibliographic Details
Main Authors: Elena Reale, Maryam Zare Jeddi, Alicia Paini, Alison Connolly, Radu Duca, Francesco Cubadda, Emilio Benfenati, Jos Bessems, Karen S. Galea, Hubert Dirven, Tiina Santonen, Holger M. Koch, Kate Jones, Craig Sams, Susana Viegas, Machera Kyriaki, Luca Campisi, Arthur David, Jean-Philippe Antignac, Nancy B Hopf
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Environment International
Subjects:
PBPK
Adverse outcome pathway
Chemical risk assessment
Biomarkers of exposure and effect
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412024000606

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http://www.sciencedirect.com/science/article/pii/S0160412024000606

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