'Glocal' robustness analysis and model discrimination for circadian oscillators.

To characterize the behavior and robustness of cellular circuits with many unknown parameters is a major challenge for systems biology. Its difficulty rises exponentially with the number of circuit components. We here propose a novel analysis method to meet this challenge. Our method identifies the...

Full description

Bibliographic Details
Main Authors: Marc Hafner, Heinz Koeppl, Martin Hasler, Andreas Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2758577?pdf=render