How to Construct a Bottom-Up Nomothetic Network Model and Disclose Novel Nosological Classes by Integrating Risk Resilience and Adverse Outcome Pathways with the Phenome of Schizophrenia

Current case definitions of schizophrenia (DSM-5, ICD), made through a consensus among experts, are not cross-validated and lack construct reliability validity. The aim of this paper is to explain how to use bottom-up pattern recognition approaches to construct a reliable and replicable nomothetic n...

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Bibliographic Details
Main Authors: Michael Maes, Aristo Vojdani, Piotr Galecki, Buranee Kanchanatawan
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Brain Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3425/10/9/645