Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists.

Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists.

BACKGROUND: Pathogen recognition by dendritic cells (DC) is crucial for the initiation of both innate and adaptive immune responses. Activation of Toll-like Receptors (TLRs) by microbial molecular patterns leads to the maturation of DC, which present the antigen and activate T cells in secondary lym...

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Bibliographic Details
Main Authors: Mirela Kuka, Roberta Baronio, Sara Valentini, Elisabetta Monaci, Alessandro Muzzi, Susanna Aprea, Ennio De Gregorio, Ugo D'Oro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2901334?pdf=render

Internet

http://europepmc.org/articles/PMC2901334?pdf=render

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